Pubdate: Thu, 01 Jun 2017
Source: Georgia Straight, The (CN BC)
Copyright: 2017 The Georgia Straight
Author: Amanda Siebert


B.C. scientists are conducting a study that is one of the first to
compare the way different strains of marijuana might affect patients
suffering from post-traumatic stress disorder (PTSD).

Leading the team of researchers is Zach Walsh, a clinical psychologist
and an associate professor at the University of B.C.'S Okanagan campus.

For Walsh, the need for research that backs up claims made by
veterans' groups, patients, and advocates has reached a critical point.

"It's the patients leading the way on this, and they're using
cannabis, so it's our job as health scientists to figure out if it's
working," Walsh tells the Georgia Straight by phone.

He says the need for empirical data is one that can't be ignored in 
light of the disorder's prevalence in Canada: in 2016, the British 
Journal of Psychiatry reported that among a group of 16 
countries-including the United States, Australia, South Africa, Iraq, 
and Israel-Canada had the highest lifetime PTSD- prevalence rate, at 9.2 

Typically, Walsh says, PTSD patients are prescribed a cocktail of
pharmaceuticals that can include antidepressants, sleeping pills, and
even anti-psychotics.

Although some drugs can be helpful in mitigating symptoms, there are
no drugs specifically formulated for patients with the disorder.
(Health Canada has approved one antidepressant drug, Paroxetine, for
PTSD, but studies have shown that it can lead to increased thoughts of
suicide among patients.)

"The nice thing about cannabis, in comparison, is that the side
effects line up much more favourably," Walsh says.

"Some might have a tough time with the cognitive effects caused by the
high, but for most people, that's a much more tolerable side effect
compared to those of other treatment options."

Walsh hopes that through the trial, patients will be able to reduce or
eliminate symptoms like irritability, anxiety, insomnia, nightmares,
and traumatic flashbacks.

The trial won't focus specifically on armed-forces veterans but on
patients with PTSD of any cause. They'll include assault victims,
first responders, and victims of motor-vehicle accidents, among others.

Every participant in the triple-blind study received a vaporizer and
is using two of three treatments for a period of three weeks each. The
first is a placebo without active ingredients. The second, a
tetrahydrocannabinol (Thc)-dominant strain, contains 12 percent of the
well-known compound. The third strain contains 12 percent each of THC
and cannabidiol (CBD). All cannabis is provided by Tilray, a
Nanaimo-based licensed producer that has partnered with UBC for the
trial, which is the largest of its kind to take place in Canada during
the last 40 years.

Walsh says that although the cannabis industry seems obsessed with
comparing the efficacy of different compounds and strains, few
studies, if any, have taken that obsession to heart.

Dr. Ian Mitchell, an emergency physician in Kamloops and the clinician
working on the trial, is responsible for the medical safety of the
patients involved.

Mitchell says it's too early to tell what the results will be, but
anecdotal evidence from patients with PTSD in his own clinical
practice has shown cannabis to be helpful. He has been referring
patients to Canada's ACMPR (Access to Cannabis for Medical Purposes
Regulations) program for the past three years.

"I have a lot of patients who are enthusiastic to be using it. I'm
seeing a lot of RCMP veterans in my practice with PTSD who are able to
sleep again-but you get a double effect, because it also helps with
pain," Mitchell tells the Straight by phone.

He adds that when patients come to him, they have often tried five or
six different medications. He says cannabis not only can help with
their PTSD symptoms but has also been effective in mitigating symptoms
of withdrawal from those other drugs.

"We've got drugs that can cause [withdrawal effects such as] sudden
death, obesity, hypertension, and it can be very damaging for people,"
he says.

"So many people I see have not gained benefit from them-and many of
them have very unpleasant withdrawal symptoms, so we don't encourage
patients to go cold turkey."

The popularity of cannabis among PTSD patients has even prompted the
federal government to conduct its own study for Canadian Armed Forces

As for the study Walsh and Mitchell are working on, it is expected to
conclude in spring 2018.
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